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10.3389/fphar.2020.00381 152 LvR.ZhaoY.WangX.HeY.DongN.MinX.et al (2024)
Contributing factors include: reduced nutritional intake (proteins, essential amino acids, competition between amino acid transporters, vitamin insufficiency [riboflavin: GSSG reductase, nicotinic acid: NADPH, pyridoxine (B 6 ): SAMe pathway], mitochondrial dysfunction: ATP deficiency, down regulation SAMe synthase, oxidation of SAMe pathway enzymes, enhanced GSH utilization: conjugation reactions (toxins, drugs), and overwhelming oxidative challenge
10.1038/s43587-021-00073-z Nat
see Figure 3 for changes in individual participants), waist circumference (6.6 cm [95% CI, 9.1 to 4.2]), total cholesterol level (7.0% [95% CI, 11.7% to 2.1%]), very low-density lipoprotein cholesterol level (11.0% [95% CI, 18.5% to 2.7%]), triglyceride level (11.0% [95% CI, 18.9% to 2.2%]), HbA 1c level (0.2 percentage points [95% CI, 0.2 to 0.1]), fasting plasma glucose level (3.9 mg/dL [95% CI, 7.2 to 0.7]), and C-reactive protein level (37.2% [95% CI, 51.7% to 18.5%]) were significantly greater with semaglutide vs with liraglutide (Table 2
Goldstein, MD, Allan L
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